NFL Football Betting: San Francisco 49ers at Arizona Cardinals

The Arizona Cardinals look to continue their domination of division foes when they open the season Sunday against the San Francisco 49ers.

The NFC champion Cardinals went 3-7 outside the division last season but won all six games against the weak West. That gave the Cardinals their first division title since 1975 despite a 9-7 overall record.

With so many weapons, the Cardinals ranked among league leaders with 26.7 points and 365.8 yards per game. They had enough offense to beat the 49ers twice, but the defense got a lot of the credit for their 29-24 home victory Nov. 10.

The Niners are encouraged going into this year after winning four of their final five games. Arizona will likely see a lot of Frank Gore, who will get most of the carries in a run-oriented offense.

The Cards are pegged as 6-point home favorites on Sunday. The road team is 7-0 ATS in the last seven meetings between these clubs.

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