NFL Football Betting: San Francisco at Indianapolis

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The San Francisco 49ers look to be in a lot of trouble when they take on the undefeated Indianapolis Colts on Sunday at Lucas Oil Stadium.

NFL football betting odds currently have the Colts listed as 13-point favorites against the 49ers.

The Colts defeated St. Louis 42-6 as a 14.5-point favorite on Sunday. Peyton Manning passed for 235 yards with three touchdowns for Indianapolis while Reggie Wayne caught seven passes for 83 yards and a touchdown in the win. The Colts are 6-0 straight up, 5-1 against the spread, and 9-1 on turf. They will be going for their seventh straight win.

The Niners lost to Houston 24-21 as 3-point underdogs in Week 7.

Alex Smith passed for 206 yards with three touchdowns and an interception for San Francisco while wide receiver Vernon Davis caught seven passes for 93 yards and three touchdowns in the loss.

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