NFL Preseason Week 2 Odds: Philadelphia at Indianapolis

Michael Vick may play tonight. (AP Images)"]

Time for Peyton Manning to get to work. There is a new left tackle, a bunch of young receivers, and an old guard coming back.

Tonight Week 2 of NFL preseason continues when the 3-point favored Philadelphia Eagles and Indianapolis Colts hook up.

The Colts plan to hold out 10 players, including six starters. Safety Antoine Bethea and defensive end Raheem Brock are both out with broken hands, Kelvin Hayden is out with a hamstring injury, and Robert Mathis will not play because of a bruised thigh. Safety Bob Sanders and kicker Adam Vinatieri won’t play either

Besides Michael Vick, Philadelphia plans to leave at least seven regulars home, including four of its projected starters on the offensive line and backup QB Kevin Kolb.

Those changes have prompted the Colts to revise their traditional preseason approach. Instead of simply trying to avoid injuries, Manning wants the starters to get a little more work.

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