Week 12 NFL Picks, Predictions & Matchups: Jacksonville vs. San Francisco

Jacksonville looks to keep rolling. (AP Images)

The Jacksonville Jaguars look for a fourth straight victory when they again head west to face the San Francisco 49ers on Sunday.

When making your NFL picks, know that the Niners are 3.5-point home favorites in this game.

Jacksonville is facing San Francisco for the first time since a 10-9 home win Dec. 18, 2008. The Jaguars are 2-0 all-time against the 49ers, but have never played at Candlestick Park.

San Francisco has dropped five of its last six, including a 30-24 defeat at Green Bay last Sunday.

After winning their last three games by a combined eight points and their last two on the final drive, the Jaguars aren’t going to take another opponent with a losing record lightly.

Alex Smith threw three of his nine touchdown passes last Sunday, but was also intercepted to increase his season total to seven.

The Jaguars are 1-5 ATS in their last six games overall.

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